4-FLUORO-2-METHYLBENZENEBORONIC ACID

4-FLUORO-2-METHYLBENZENEBORONIC ACID - Names and Identifiers

Name	4-Fluoro-2-methylbenzeneboronic acid
Synonyms	AKOS BRN-0102 4-Fluoro-o-tolylboronic acid 4-FLUORO-O-TOLYLBORONIC ACID 4-Fluoro-2-methylbenzenboronic acid 4-Fluoro-2-Methylbenzenboronic acid 4-FLUORO-2-METHYLPHENYLBORONIC ACID 4-Fluoro-2-methylphenylboronic acid 4-Fluoro-2-Methylphenyl Boronic Acid 4-FLUORO-2-METHYLBENZENEBORONIC ACID 4-Fluoro-2-methylbenzeneboronic acid Boronicacid, B-(4-fluoro-2-methylphenyl)-
CAS	139911-29-8
EINECS	642-527-4
InChI	InChI=1/C7H8BFO2/c1-5-4-6(9)2-3-7(5)8(10)11/h2-4,10-11H,1H3
InChIKey	IQMLIVUHMSIOQP-UHFFFAOYSA-N

4-FLUORO-2-METHYLBENZENEBORONIC ACID - Physico-chemical Properties

Molecular Formula	C7H8BFO2
Molar Mass	153.95
Density	1.20±0.1 g/cm3(Predicted)
Melting Point	191-196°C(lit.)
Boling Point	277.4±50.0 °C(Predicted)
Flash Point	121.6°C
Solubility	Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0.00218mmHg at 25°C
Appearance	White to white-like powder
Color	White to off-white
pKa	8.75±0.58(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.505
MDL	MFCD02093072

4-FLUORO-2-METHYLBENZENEBORONIC ACID - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing.
WGK Germany	3
HS Code	29163990
Hazard Class	IRRITANT

4-FLUORO-2-METHYLBENZENEBORONIC ACID - Introduction

4-fluoro-2-methylphenylboronic acid, chemical formula C7H7BF4, is an organic compound. The following is a description of the properties, uses, preparation and safety information of this compound:

Nature:
-4-Fluoro-2-methylphenylboronic acid is a solid, white crystal or crystalline powder at room temperature.
-Its melting point is about 140-144°C, and its boiling point exceeds 300°C.
-This compound is less soluble in water and more soluble in organic solvents such as ether and ethanol.
-Its molecular structure contains a fluorine atom, a methyl group and a benzene ring structure.

Use:
- 4-fluorine -2-methyl benzene boronic acid is often used as an important reagent in organic synthesis.
-It can be used to prepare other organic compounds, such as aromatic ethers, amides and borate esters.
-In the field of drug development, it is also often used as a drug intermediate synthesis.
-The compound also has some applications in materials science, such as the synthesis of liquid crystal materials and complexes.

Preparation Method:
The preparation of-4-fluoro-2-methylphenylboronic acid is usually accomplished by the reaction of boric acid with p-fluorotoluene.
-In the reaction, p-fluorotoluene first reacts with triethylamine to form p-fluorotolyl triethylamine salt, and then reacts with boric acid to obtain the product.

Safety Information:
-This compound should follow general laboratory safety practices, such as wearing gloves and protective glasses, avoiding inhalation and skin contact.
-It may cause irritation and damage to the eyes, skin and respiratory tract, so it should be stored and handled properly.
-During handling and storage, it should be separated from oxidants, strong acids and strong bases to avoid hazards due to reactions with these substances.
-Pay attention to avoid dust or gas during handling, as this may cause health hazards.

Last Update：2024-04-09 20:49:11